Document 0794
 DOCN  M94B0794
 TI    Pediatric HIV associated non-Hodgkin's lymphomas (Meeting abstract).
 DT    9412
 AU    Shad A; Bhatia K; Hamdy N; Mueller B; Pizzo P; Whang Peng J; Jaffe E;
       Magrath I; Pediatric Branch, Pathology Dept., NCI, Bethesda, MD 20892
 SO    Proc Annu Meet Am Assoc Cancer Res; 35:A1140 1994. Unique Identifier :
       AIDSLINE ICDB/94602826
 AB    HIV infected children, like HIV infected adults, are at increased risk
       for development of non-Hodgkin's lymphomas (NHL). However, there is very
       little information available on the histological, cytogenetic and
       molecular features of pediatric HIV associated NHLs. We present here the
       pathological and biological features of 5 such pediatric lymphomas.
       Histologically, unlike non-immunosuppressed children, where Burkitt's
       lymphoma is the most common form of NHL seen, pediatric HIV associated
       NHLs are more variable. 3 tumors analyzed were small non-cleaved cell
       lymphomas (SNCC), 1 large cell immunoblastic lymphoma, 1 anaplastic
       large cell lymphoma (Ki-1+), and 1 B cell lymphoma with plasmacytoid
       features. Cytogenetic studies demonstrated that 2 of 3 SNCC lymphomas
       had t(8;14) while 1 had t(9;19); the large cell immunoblastic lymphoma
       had an inv(12). By Southern blot analyses, both tumors with t(8;14) had
       a rearrangement of the c-myc gene. EBV was identified in 2 SNCC
       lymphomas, but not in the other histological subtypes. Only 2 SNCC
       lymphomas carried a mutated p53. These findings suggest that the
       spectrum of lymphoma subtypes is broader in a pediatric HIV population
       compared to that seen in non-immunosuppressed children.
 DE    Blotting, Southern  Child  Chromosome Aberrations  Gene Expression
       Regulation, Neoplastic/PHYSIOLOGY  Human  Lymphoma,
       AIDS-Related/CLASSIFICATION/GENETICS/*PATHOLOGY  Neoplasm Staging  Tumor
       Markers, Biological/GENETICS  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).